O'Keeffe's Working Hands Night Treatment – Post-Shift Hand Recovery for Nurses and Healthcare Staff, 7 oz
O'Keeffe's Working Hands Night Treatment – Post-Shift Hand Recovery for Nurses and Healthcare Staff, 7 oz
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Why you'll love it
- Visible improvement in as little as one night delivers fast, tangible payoff over regular lotions
- Trusted #1 hand cream brand in America reduces risk for first-time buyers
- Non-greasy finish means it can be applied right before bed without ruining sheets or pajamas
- Hypoallergenic, unscented, and diabetic-safe formula removes worry for sensitive or medically vulnerable skin
- Overnight passive treatment fits into existing bedtime routine without adding daytime hassle
- Larger 7 oz tube and multi-pack options offer better per-ounce value for chronic sufferers
Perfect for
- Overnight restorative treatment applied at bedtime to repair cracked hands by morning
- Post-handwashing moisture seal applied in the bathroom after sanitizing or washing
- After-bath or shower hand care to lock in hydration when skin is most receptive
- Long-term maintenance for diabetes-related or age-related extreme hand dryness
- Stocking multiple bathrooms or sinks via 7 oz twin-pack bulk supply



Product Information
Get your hands back overnight: O’Keeffe’s Working Hands Night Treatment is a calming yet intense, restorative hand cream for cracked, dry hands that works while you sleep; From the #1 hand cream brand in America*
Dry hands nighttime remedy: O'Keeffe's Night Treatment Cream for extremely dry hands is a calming yet intense, restorative hand cream that relieves extremely dry, cracked hands while you sleep; Shows visible improvements in as little as one night
Made with deep conditioning oils: Our Night Treatment formula leaves your hands feeling soothed and moisturized overnight without leaving any greasy feeling behind
Recommended use: For best results, apply after hand washing, after bathing, and at bedtime - these are the most effective times for moisturizing extremely dry hands and skin
Hypoallergenic: O'Keeffe's Working Hands is unscented, non-greasy and safe for people with diabetes; Our 7 ounce tube is perfect for a reliable at-home supply of comfort and moisture
O’Keeffe’s Working Hands Night Treatment hand lotion for dry hands is a calming yet intense, restorative hand cream that is designed to instantly relieve extremely chapped, dry hands while you sleep. O'Keeffe's Working Hands Night Treatment contains natural grapefruit and lavender oil while being hypoallergenic. Made with deep conditioning oils. This formula won't leave a greasy feel on your hands after you use it. O'Keeffe's Night treatment locks in moisture and works while you sleep. See visible results to your hands in at as little as one night.
Items Details
Frequently Asked Questions
Will this help nurses and healthcare workers recover from constant hand washing?
Yes, it is a top choice for nurses, doctors, and healthcare staff who wash and sanitize dozens of times per shift, and applying it at bedtime helps reverse the sanitizer-induced dryness overnight.
Can I apply this between shifts in a hospital break room?
Yes, the non-greasy finish absorbs in minutes, so you can apply it during a break, put gloves back on, and return to work without slippery residue or interference with patient care.
Does this work for someone with frequent hand-sanitizer-related dryness?
Absolutely, the deep conditioning formula is designed to replenish the moisture stripped away by alcohol-based sanitizers, and nightly use helps prevent the painful cracking that comes with constant sanitizing.
Can caregivers use this on elderly patients or family members they care for?
Yes, the hypoallergenic, diabetic-safe, unscented formula is gentle enough to apply to older adults or sensitive patients as part of a daily hand-care routine.
Will this interfere with wearing latex or nitrile gloves at work?
No, because the non-greasy finish absorbs fully, so you can apply it, wait a minute, and put on gloves without slippage or compromised grip during patient care or lab work.
Is this appropriate for keeping at a hospital bedside or nurses' station?
Yes, the 7 oz tube is a practical size for shared use in a break room, nurses' station, or staff bathroom, and the secure cap keeps it hygienic in clinical environments.
Can teachers, food service workers, or childcare providers use this daily?
Yes, anyone who washes hands frequently for work will benefit from the overnight repair formula, and the unscented finish will not interfere with food handling or close interaction with children.
Will this help with dryness caused by wearing gloves for long shifts?
Yes, glove-induced sweating followed by drying can leave hands irritated, and the overnight conditioning helps restore the skin barrier that gets compromised by prolonged occlusion and friction.
Can I use this on a night shift without it affecting my sleep?
Yes, the unscented formula will not stimulate or disrupt your sleep, and the quick-absorbing finish means you can apply it, get into bed, and fall asleep without any residue on your sheets.
Does the 7 oz size make sense for a household with multiple healthcare workers?
Yes, the twin-pack is ideal for shared bathrooms or multiple staff members in one household, and the per-ounce value is better for chronic, high-frequency users.
How does this compare to the lotion dispensers provided at hospitals?
Hospital lotions are designed for quick, light moisturizing between tasks, whereas this is a concentrated overnight treatment that does the deep repair that workplace lotions cannot achieve in the few seconds clinicians have to apply them.
Is this better than wearing cotton gloves with regular lotion overnight?
Gloves help, but the time-release formula in this cream is engineered to deliver deep conditioning over several hours of sleep, so it outperforms basic lotion-and-glove routines for sanitizer-damaged hands.
Can this help me stay comfortable during long shifts?
Yes, by treating the underlying cracking and dryness overnight, you wake up with hands that are less painful, less prone to splitting, and more comfortable through a full day of washing and gloving.
Is the investment worth it for someone whose hands are part of their job?
For healthcare workers, caregivers, and frequent hand washers, healthy hands are a professional necessity, and the cost per night is minimal compared to the comfort, productivity, and reduced pain it delivers.
How do I use O'Keeffe's Working Hands Night Treatment for best results?
Apply a small amount to clean, dry hands as the last step of your evening routine, massaging it into the knuckles, cuticles, and any cracked areas, then leave it on overnight while you sleep so the time-release formula can repair the skin barrier by morning.
Can I use this cream during the day as well, or only at night?
You can use it any time, but it is specifically formulated as an overnight treatment with deep conditioning oils, so applying it at bedtime gives it several uninterrupted hours to work without being washed or wiped off.
How long does one 7 oz tube last with nightly use?
A 7 oz tube used once per night typically lasts about two to three months, and the twin-pack stretches that further for chronic users or shared bathrooms.
Is this hand cream compatible with cotton sleep gloves or overnight gloves?
Yes, it works very well under cotton gloves for an enhanced deep-conditioning treatment, and because the finish is non-greasy, you can also sleep without gloves and still get full repair benefits.
Will this tube fit in a standard bathroom holder, purse, or travel bag?
The 7 oz tube is slim enough for most bathroom cup holders, and the 3 oz travel pack of 2 is designed specifically for purses, gym bags, and carry-on luggage.
What is included in the box when I order this product?
Depending on the variant you select, you receive either a single 7 oz squeeze tube, a 7 oz twin-pack, or a 3 oz travel pack of 2 tubes, all with secure flip caps and ready to use immediately with no additional setup.
Is this product tested on animals or made with animal-derived ingredients?
O'Keeffe's is a trusted American brand focused on effective, sensitive-skin-friendly formulations, and you should review the current packaging or brand site for the most up-to-date information on cruelty-free status and ingredient sourcing.
How should I store the tube to keep it from drying out or going bad?
Store it at room temperature with the cap firmly closed, away from direct sunlight and extreme heat, and it will stay fresh and effective for the full life of the tube.
What is the difference between a hand cream and a hand lotion?
Hand lotions are typically lighter, water-based products designed for quick daytime moisturizing, while hand creams like this one are richer, oil-based treatments built for deep, long-lasting repair of cracked, dry, or compromised skin.

